| Instructor(s) | Dr. Virgilio Valente [Coordinator] Office: ENG450 Phone: (416) 979-5000 x 553728 Email: vvalente@torontomu.ca Office Hours: Tue 1pm-3pm (weeks 2-13) | ||||||||||||||
| Calendar Description | Biophysical and chemical principles of biomedical microelectromechanical systems (bioMEMS) for the measurement of biological phenomena and clinical applications. micro-and nano-scale devices for the manipulation of cells and biomolecules. Topics include solid-state transducers, optical transducers, electrochemical transducers, biomedical microelectronics, microfluidics, and hybrid integration of microfabrication technology. | ||||||||||||||
| Prerequisites | BME 423 and BME 674 and BME 634 | ||||||||||||||
| Antirequisites | None | ||||||||||||||
| Corerequisites | None | ||||||||||||||
| Compulsory Text(s): |
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| Reference Text(s): |
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| Learning Objectives (Indicators) | At the end of this course, the successful student will be able to:
NOTE:Numbers in parentheses refer to the graduate attributes required by the Canadian Engineering Accreditation Board (CEAB). | ||||||||||||||
| Course Organization | 3.0 hours of lecture per week for 13 weeks | ||||||||||||||
| Teaching Assistants | - Kanhchana Ly (kanhchana.ly@torontomu.ca) - Stephanie McGinnity (stephanie.mcginnity@torontomu.ca) | ||||||||||||||
| Course Evaluation |
Note: In order for a student to pass a course, a minimum overall course mark of 50% must be obtained. In addition, for courses that have both "Theory and Laboratory" components, the student must pass the Laboratory and Theory portions separately by achieving a minimum of 50% in the combined Laboratory components and 50% in the combined Theory components. Please refer to the "Course Evaluation" section above for details on the Theory and Laboratory components (if applicable). | ||||||||||||||
| Examinations | Midterm exam will be held in Week 7 of the course on Feb 27 at 9am in DCC350, lasting for 1 hour, closed book and will cover all material from Weeks 1-6. In case of missed midterm, a makeup midterm will be scheduled. Final exam during exam period will be 2 hours, closed-book and will cover all material after the midterm with focus on topics covered after the mid-term. | ||||||||||||||
| Other Evaluation Information | Labs will start in week 3. All labs will be related to the design and simulation of bioMEMS components/devices using the software package of Coventorware. The laboratory manuals will be posted on course shell on D2L. The introductory lab will be worth 5%. Labs 1 and 2 will worth 7.5% each. Course Project: Students will complete a course project on a topic of their choosing. Students will work in groups of 4 members (where applicable). Groups must be formed and group topic selected by week 4 of the term and must be approved by the course instructor (topics entered in the provided spreadsheet by 5pm Friday week 4). Details of the term project will be given during class and posted in the Project folder in the BME804 course shell. Project assessment: 1 - Project summaries due in week 10 in D2L 3 - Final presentations: Each group will present their course project in a 20/25-min presentation. Each member of the group must present (approx 5-6 min each). USE OF AI TOOLS You may use Generative AI (e.g. ChatGPT, Grammarly, Perplexity, DeepL Translator) in this course. However: 1. If you misrepresent source material (as AI often does), that will be considered a breach of Policy 60 2. If your citations are not genuine (AI often makes up references), that will be considered a breach of Policy 60 3. You are required to write a clear declarative statement describing how AI tools were used and the extent of its contribution to the final submission. | ||||||||||||||
| Other Information | Lectures: Friday 8:00am - 11:00am DCC350 Lectures in general consist of: - Lecture material (course topics, examples etc.) - Group activities (discussions, project work) - Offline coursework (reading material, assignments, watch prerecoded videos (where applicable), self-organized group meetings etc.) | ||||||||||||||
Week | Hours | Chapters / | Topic, description |
|---|---|---|---|
1 | 3 | Topic 1. Introduction to MEMS and bioMEMS. Introduction to bio-MEMS and their applications. Current use of bio-MEMS devices. | |
2 | 3 | Topic 2. Silicon Microfabrication Part I. Mask creation, silicon wafer preparation, photolithography, photoresist (positive or negative), UV exposure and development, etching methods, resist stripping. | |
3 | 3 | Topic 3. Silicon Microfabrication Part II. Thin films, thin film processes, deposition, micromachining, bonding. | |
4 | 3 | Topic 4. Soft Fabrication and Polymers: Soft lithography, Micromolding, 3-D Photopolymerization, Smart polymers and hydrogels, Nanomedicine techniques, Thick-film technologies. | |
5 | 3 | Topic 5: Microfluidics part 1: microfluidics lab-on-a-chip materials. | |
6 | 3 | Topic 6: Microfluidics part 2: fluid dynamic principles, electrophoresis, streaming potential, applications to lab-on-a-chip devices. | |
7 | 3 | Midterm (1 hour, Friday 27 Feb at 9am) | |
8 | 3 | Topic 7: Sensing principles and microsensors. thermal, mechanical, flow, magnetic and optical sensors. | |
9 | 3 | Topic 8: Microactuators & Drug delivery systems. Passive, active, bio-MEMS as drug delivery systems | |
10 | 3 | Topic 9. Biosensors | |
11 | 3 | Topic 10. Packaging Power and Safety: System integration, RF safety, energy harvesting, power transfer data transmission | |
12 | 3 | No lecture (Easter Friday) | |
13 | 3 | Review |
Week | L/T/A | Description |
|---|---|---|
3-4 | 1 | Lab 1- Introduction to ConventorWare & design example. |
5-8 | 2 | Lab 2 - Electrostatic 2D micro-mirror design and simulation. |
9-11 | 3 | Lab 3 - Electro-thermal micro-gripper simulation. |
Students are reminded that they are required to adhere to all relevant university policies found in their online course shell in D2L and/or on the Senate website
Refer to the Departmental FAQ page for furhter information on common questions.
The University Libraries provide research workshops and individual consultation appointments. There is a drop-in Research Help desk on the second floor of the library, and students can use the Library's virtual research help service to speak with a librarian, or book an appointment to meet in person or online.
You can submit an Academic Consideration Request when an extenuating circumstance has occurred that has significantly impacted your ability to fulfill an academic requirement. You may always visit the Senate website and select the blue radio button on the top right hand side entitled: Academic Consideration Request (ACR) to submit this request.
For Extenuating Circumstances, Policy 167: Academic Consideration allows for a once per semester ACR request without supporting documentation if the absence is less than 3 days in duration and is not for a final exam/final assessment. Absences more than 3 days in duration and those that involve a final exam/final assessment, always require documentation. Students must notify their faculty/contract lecturer once a request for academic consideration is submitted. See Senate Policy 167: Academic Consideration.
Longer absences are not addressed through Policy 167 and should be discussed with your Chair/Director/Program to be advised on next steps.
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