| Instructor(s) | Steven Tran [Coordinator] Office: LKS735 Phone: TBA Email: s10tran@torontomu.ca Office Hours: Mondays 11:00am - 12:00pm | ||||||||||||||
| Calendar Description | Biophysical and chemical principles of biomedical microelectromechanical systems (bioMEMS) for the measurement of biological phenomena and clinical applications. micro-and nano-scale devices for the manipulation of cells and biomolecules. Topics include solid-state transducers, optical transducers, electrochemical transducers, biomedical microelectronics, microfluidics, and hybrid integration of microfabrication technology. | ||||||||||||||
| Prerequisites | BME 423 and BME 674 and BME 634 | ||||||||||||||
| Antirequisites | None | ||||||||||||||
| Corerequisites | None | ||||||||||||||
| Compulsory Text(s): |
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| Reference Text(s): |
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| Learning Objectives (Indicators) | At the end of this course, the successful student will be able to:
NOTE:Numbers in parentheses refer to the graduate attributes required by the Canadian Engineering Accreditation Board (CEAB). | ||||||||||||||
| Course Organization | 3.0 hours of lecture per week for 13 weeks | ||||||||||||||
| Teaching Assistants | Steven, Sina | ||||||||||||||
| Course Evaluation |
Note: In order for a student to pass a course, a minimum overall course mark of 50% must be obtained. In addition, for courses that have both "Theory and Laboratory" components, the student must pass the Laboratory and Theory portions separately by achieving a minimum of 50% in the combined Laboratory components and 50% in the combined Theory components. Please refer to the "Course Evaluation" section above for details on the Theory and Laboratory components (if applicable). | ||||||||||||||
| Examinations | Midterm exam will be held in Week 9 of the course on Mar 5 at 12pm, lasting for 3 hours, closed book and will cover all material from Weeks 1-6. In case of missed midterm, a makeup midterm will be scheduled. Final exam during exam period will be three hours, closed-book and will cover all material from Weeks 1-12. | ||||||||||||||
| Other Evaluation Information | Labs will start in week 3. All labs will be related to the design and simulation of bioMEMS components/devices using the software package of Coventorware. The laboratory manuals will be posted on course shell on D2L. The introductory lab will be worth 5%. Labs 1 and 2 will worth 7.5% each. Course Project: Students will complete a course project on a topic of their choosing. Students will work in groups of 4 members (where applicable). Groups must be formed and group topic selected by week 4 of the term and must be approved by the course instructor (topics entered in the provided spreadsheet by 5pm Friday week 4). Details of the term project will be given during class and posted on the BME804 course shell. Project assessment: 1 - Project outline due in week 6 in D2L (20%) 2 - Project description due in week 10 in D2L (30%) 3 - Final presentations: Each group will present their course project in a 30-min presentation. Each member of the group must present (approx 7-8 min each). (50%) | ||||||||||||||
| Other Information | Lectures: Wednesday 12:00pm - 3:00pm DCC103 Lectures in general consist of: - Lecture material (course topics, examples etc.) - Group activities (discussions, project work) - Offline coursework (reading material, assignments, watch prerecoded videos (where applicable), self-organized group meetings etc.) | ||||||||||||||
Week | Hours | Chapters / | Topic, description |
|---|---|---|---|
1 | 3 | Lecture Topic 1: Introduction to MEMS and bioMEMS. Introduction to bio-MEMS and their applications. Current use of bio-MEMS devices. | |
2 | 3 | Lecture Topic 2: Miniaturizing devices, silicon microfabrication (photolithography, UV exposure, etching methods, resist stripping). | |
3 | 3 | Lecture Topic 3 : Micro total analysis systems (microTAS), micromachining, stop flow lithography. | |
4 | 3 | Lecture Topic 4: Life at the low Reynolds number, cell mechanics at low Reynolds number, applications to microTAS devices. | |
5 | 3 | Lecture Topic 5: Microfluidics part 1: microfluidics lab-on-a-chip materials. | |
6 | 3 | Lecture Topic 6: Microfluidics part 2: fluid dynamic principles, electrophoresis, streaming potential, applications to lab-on-a-chip devices. | |
7 | 3 | No class - study week. | |
8 | 3 | Lecture Topic 7: Sensing principles in bio-MEMS. thermal, mechanical, flow, magnetic and optical sensors. | |
9 | 3 | Midterm | |
10 | 3 | Lecture Topic 8: Drug delivery systems. Passive, active, bio-MEMS as drug delivery systems, using bio-MEMS for downstream applications of drug delivery systems. | |
11 | 3 | Lecture Topic 9: Bio-MEMS for cell biology. | |
12 | 3 | Lecture Topic 10: Bio-MEMS for molecular biology. | |
13 | 3 | Lecture Topic 11: Designing economic, informative and accessible bio-MEMS devices. |
Week | L/T/A | Description |
|---|---|---|
3-4 | 1 | Lab 1- Introduction to ConventorWare & design example. |
5-9 | 2 | Lab 2 - Electrostatic 2D micro-mirror design and simulation. |
10-12 | 3 | Lab 3 - Electro-thermal micro-gripper Simulation. |
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