Course Outline (W2024)

BME423: Biomaterials

Instructor(s)Dr. Muhammad Hasibul Hasan [Coordinator]
Office: EPH 312 E
Phone: email instructor
Office Hours: TBA
Calendar DescriptionThe principles of materials science and engineering with particular attention to topics most relevant to biomedical engineering. The structure-property relationships of metals, ceramics, polymers, and composites as well as skin, bone, cartilage, ligament, and vasculature; extensive treatment of the properties unique to materials' surfaces. Behavior of materials in the physiological environment.
PrerequisitesBLG143 and BME323




Compulsory Text(s):
  1. Please obtain the BME423 laboratory manual from the Ryerson bookstore before attending your first lab.
Reference Text(s):
  1. Biomaterials: An Introduction, J. Park and R.S. Lakes, Springer, 2007
  2. Biomaterials: A Basic Introduction, Q. Chen and G. Thouas CRC Press, 2016
  3. Advanced Biomaterials: Fundamentals, Processing, and Applications, B. Basu, D.S. Katti and A. Kumar - John Wiley and Sons 2009
  4. Introduction to Dental Materials - 3rd Edition R. van Noort - Mosby, 2008
  5. An Introduction to tissue-Biomaterial Interactions, K.C. Dee, D.A. Puleo and R. Bizios - John Wiley and Sons, 2002
  6. Introduction to Biomedical Engineering - 2nd Edition M.M. Domach - Pearson/Prentice Hall, 2009
Learning Objectives (Indicators)  

At the end of this course, the successful student will be able to:

  1. Apply a basic knowledge of science, conduct experiments on science principles and interpret the obtained results, develop further knowledge of science in support of application to engineering problems. (1a)
  2. Interpret the results both qualitatively and quantitatively and check conclusions against objectives. (2a)
  3. Make valid assumptions based on available information. (2b)
  4. Make accurate use of technical literature and other information sources, determine the data that are appropriate to collect. recognize the characteristics of, and distinguish between experimental and investigations and theory. (3a)
  5. Interpret experimental data using scientific technique and analysis. (5a)
  6. Develop the understanding of the regulatory body and they shared responsibility for sustainable development (9a)
  7. Source and Use up to date information for evaluation. (12a)

NOTE:Numbers in parentheses refer to the graduate attributes required by the Canadian Engineering Accreditation Board (CEAB).

Course Organization

3.0 hours of lecture per week for 13 weeks
2.0 hours of lab per week for 12 weeks
0.0 hours of tutorial per week for 12 weeks

Teaching AssistantsTBA
Course Evaluation
assignment 20 %
Midterm Exam 20 %
Final Exam 40 %
Practicum 20 %
TOTAL:100 %

Note: In order for a student to pass a course, a minimum overall course mark of 50% must be obtained. In addition, for courses that have both "Theory and Laboratory" components, the student must pass the Laboratory and Theory portions separately by achieving a minimum of 50% in the combined Laboratory components and 50% in the combined Theory components. Please refer to the "Course Evaluation" section above for details on the Theory and Laboratory components (if applicable).

ExaminationsFinal exam, During exam period, 3 hours, closed-open book (covers weeks 1-13).
 Midterm exam 2 hrs  (7th week of the semester, covers weeks 1-6)
 Term report (due on the 13th week of the semester)
 All the tests, term report and Final exam will be conducted in person.
Other Evaluation InformationNote: In order to pass the course, a student must: (1) achieve an overall score for the course of 50% or higher AND (2) obtain a passing grade (ie 30/60) on the midterm and final examination.
 All of the required course-specific written reports/assignments/labs will be assessed not only on their technical/academic merit, but also on the communication skills exhibited through them.
Other InformationCOURSE LEARNING OUTCOMES: When students successfully complete this course they will understand the concepts behind developing medical materials and processes, the accreditation procedures that are used to ensure device and process safety and efficacy and how these procedures are applied using laboratory and clinical techniques.
 TOPICS COVERED: (1) history of medical and dental science, (2) bacteria, (3) medical devices, (4) medical processes, (5) tissue engineering, (6) introduction to FDA accreditation.

Course Content



Chapters /

Topic, description



Introduction to biomaterials, biological response to biomaterials, types of biomaterials, processing of biomaterials, biomaterial product testing, important properties of biomaterials, principles of chemistry including atomic structure and bonding.
 Chemical structure of biomaterials: crystal structure, point defect and diffusion of metals, structure and point defect of ceramics, structure and synthesis of polymers, methods of polymerization, copolymer, material characterization techniques, X-ray diffraction.
 Physical properties of biomaterials: crystallinity, linear, planar and volume defects, polymer crystallinity, thermal transitions of crystalline and non-crystalline materials, thermal analysis techniques, differential scanning calorimetry.



Mid-Term Assignment



Mechanical properties of biomaterials: mechanical testing modes methods results and calculations hardness impact tests fracture fatigue methods to improve mechanical properties mechanical analysis techniques.
 Degradation of biomaterials: corrosion/degradation of metals and ceramics fundamentals of electrochemistry and corrosion contributions of processing parameters mechanical and biological environments means of corrosion control degradation of polymers biodegradable materials.
 Surface properties of biomaterials: concepts in surface chemistry and biology physicochemical surface modification techniques biological surface modification techniques surface properties and degradation patterning techniques for surfaces.
 Polymer composite materials cortical bone and trabecular bone skin cartilage ligament and vaculature.

Laboratory(L)/Tutorials(T)/Activity(A) Schedule





Lab 1

Construction of atomic models


Lab 2

Identification of materials by X-ray diffraction


Lab 3

Corrosion experiments of materials


Lab 4

Impact and hardness testing


Lab 5

Tensile properties of polymeric materials.

University Policies & Important Information

Students are reminded that they are required to adhere to all relevant university policies found in their online course shell in D2L and/or on the Senate website

Refer to the Departmental FAQ page for furhter information on common questions.

Important Resources Available at Toronto Metropolitan University


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